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You will know your next step from this step.

INFORMATION FROM THE CANCER CONTROL SOCIETY CONVENTION OF 2017 – INTERNATIONAL TREATMENTS.

Hello Tuesday,

We must learn to enjoy every minute of your life. There is only one happiness in this life, to love and be loved. The first step toward success is taken when you refuse to be a captive of the environment in which you first find yourself.

There’s this old saying, “No one can hit their target with their eyes closed. To reach a great height, a person needs to have great depth. Aim for the moon, if you miss, you may hit a star. You can’t hit a target if you don’t know what it is.”

In all areas of our lives, it’s important to know where we are headed, what our goals are, what we are working toward, right? Take the first step!

I don’t know about you but Dan and I like to know what’s ahead of us. We appreciate having the awareness of what to expect and the feeling of control that comes with it. Life in 2020 has been a perfect example of expectation versus reality for the world. Each year we walk into January with goals, expectations and so full of hope… maybe it was just me but something about the year 2020 felt so much different. Images of the amazing things that Dan and I would accomplish, the trips and seeing family. Then reality of life (whatever you want to call it) came along and 2020 has turned into one disappointment after another. I’ve found myself hoping that it has been all a bad dream. But then I realize I must take one step after another to make a difference.

STOP AND SMELL THE ROSE'S

Good day Tuesday☑️ Don't wait for things to be perfect. Celebrate your life by enjoying it to the fullest 🆗 Stop and smell the roses🌹#inspiration#motivation#llivelifetothefullest

All I have to do is take one single step. It’s a well-worn step, clearly taken by Dan and I many times.

It’s a step toward hope. It is courage. It may lead anywhere or everywhere or maybe nowhere but not to know until taken. Then suddenly the next step comes into focus and the courage surrounded by hope makes taking it so much easier.

Are you facing a similar staircase or situation that is cloudy and unseen? Take the step. It’s just one and that means you can’t see so far ahead that you forget to be present where you are. Step into faith within yourself, claim the courage, and wrap yourself in hope. Take the step.

It’s your place in the world; it’s your life. Go on and do all you can with it, and make it the life you want to live.”

For Dan and I, we have made the first step and decided to explore nature and focus on health, regardless of the uncertain times we are facing.

Continuing on INFORMATION FROM THE CANCER CONTROL SOCIETY CONVENTION OF 2017 – INTERNATIONAL TREATMENTS. Today I will be blogging on Natural Killer cell therapy.

Natural cells are a type of cytotoxic lymphocyte that constitutes a major component of the innate immune system.

Natural cells play a major role in the rejection of tumors and cells infected by viruses. They kill cells be releasing small cytoplasmic granules of proteins called perforin and granzyme that causes the target cell to die by apoptosis.

Natural killer cells have been at the forefront of immunology for two decades. During that time a great amount of information about these cells has been obtained. They are important in anti-infectious and antitumor defense and shape the adaptive immune response. In addition, they can act as immune-regulatory cells. In recent years, the therapeutic potential of natural killer cells in cancer immunotherapy has become increasing evident.

Natural killer cells are unique; however, as they have the ability to recognize stressed cells in the absence of antibodies and MHC, allowing for a much faster immune reaction.

What is Natural killer cell Therapy?

The discovery of NK cells occurred in the early 1970s by Swedish professor Rolf Kiessling during research on the well-characterized ability of T-lymphocytes to lyse tumor cells against which they had been previously immunized. During these experiments, investigators consistently observed what was termed a natural reactivity, that is, a certain population of cells seemed to be able to lyse tumor cells without having been previously sensitized to them. As these discoveries were incompatible with the established model at the time, many of these observations were initially considered artifacts.

However, by 1973, 'natural killing' activity was established across a wide variety of species, and the existence of a separate lineage of cells possessing this ability was postulated. Through the use of monoclonal antibodies, natural killing ability was mapped to the subset of large, granular lymphocytes known today as natural killer cells.

The cells were named "natural killer" because of the initial notion that they do not require activation in order to kill cells that are "missing-self" recognition ("missing-self" recognition is a term used to describe cells with low levels of MHC class I cell surface marker molecules — a situation that could arise due to viral infection, or in tumors under strong selection pressure of killer T cells).

With the discovery of activating receptors almost two decades after the discovery of the inhibitory receptors these cells continue to be called by the same name, though “natural” no longer means the same thing. The term “natural killer” continues to be justified by:

morphology characteristic of activated cytotoxic lymphocytes, large size, high protein synthesis activity in the abundant endoplasmic reticulum (ER), and preformed granules the mature state (does not require much new protein synthesis and remodeling before starting to kill).

The road of life twists and turns and no two directions are ever the same. Yet our lessons come from the journey, not the destination. - Don Williams, Jr.

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